Curtis AB, Ridzon R, Vogel R, McDonough S, Hargreaves J, Ferry J, Valway S, Onorato IM
Young children rarely transmit tuberculosis. 1 2 In five recently published reports of school-based outbreaks, all source patients were adults or adolescents. 3 4 5 6 7 Tuberculosis in young children is rarely infectious, because young children are less likely than adults to have a productive cough…

N Engl J Med 341:1491, November 11, 1999 Original Article

  • Barton LL, Lepage P, De Rosa FG, Craven DE, Meyer BC, Jasmer RM, Nahid P, Hopewell PC
    tuberculosis may be considered for treatment of LTBI [latent tuberculosis infection] if their reaction to tuberculin skin test is ≥15 mm.” 2 One might view this person as being in an intermediate-risk group, since she is in a setting in which she would expose and potentially infect many children

    N Engl J Med 348:1292, March 27, 2003 Correspondence

  • Jasmer RM, Nahid P, Hopewell PC
    …essential that active tuberculosis be ruled out ( Figure 1). Treatment Regimens The first choice for treatment of latent tuberculosis infection is isoniazid ( Table 3). Current guidelines recommend a duration of at least six and preferably nine months in adults and nine months in children. For persons with…

    N Engl J Med 347:1860, December 5, 2002 Clinical Practice

    Related Searches: Tuberculosis | Tb | Latent Tuberculosis | Ppd

  • Small PM, Fujiwara PI
    …necessary in children. During treatment, all patients should be asked about symptoms, and monitored for adverse effects on a monthly basis. A chest radiograph should be obtained at the beginning of treatment to help establish the diagnosis. For culture-negative cases of tuberculosis, the response to…

    N Engl J Med 345:189, July 19, 2001 Review Article

  • Sterling TR, Haas DW
    …newer tests that are more specific for M. tuberculosis. These tests include whole-blood assays that detect the release of interferon gamma by cells incubated ex vivo with M. tuberculosis peptides or proteins. In May 2005, one such assay, the QuantiFeron-TB Gold (QFT-G) test, was approved by the Food…

    N Engl J Med 355:118, July 13, 2006 Perspective

  • Kashyap AS, Kashyap S, Pasternack MS
    …not recommended for young children, in whom visual complications are difficult to monitor. 2, Dr. Pasternack replies: To the Editor: The need for initial multidrug antituberculous chemotherapy is well established in the current era of possible drug-resistant tuberculosis. The potential ocular toxicity…

    N Engl J Med 341:1857, December 9, 1999 Correspondence

  • Harris JB, Michelow IC, Westra SJ, Kradin RL
    …developed 1 month after arriving in India. Infants, unlike older children or adults, often present with symptomatic primary tuberculosis 3 to 8 weeks after exposure, and disseminated disease, such as miliary or meningeal tuberculosis, may develop 2 to 6 months after exposure. 3 Are the other clinical…

    N Engl J Med 359:178, July 10, 2008 Case Records of the Massachusetts General Hospital

  • O’Sullivan BP, Erickson LA, Niles JL
    …admission, but had not been confirmed by biopsy. A tuberculin test 12 months before admission was negative, and she had had no known exposure to tuberculosis. The results of laboratory studies performed nine months before admission are shown in Table 1. During the eight months before admission, the girl…

    N Engl J Med 347:1009, September 26, 2002 Case Records of the Massachusetts General Hospital

  • Horsburgh CR Jr
    …Clemens von Pirquet has developed a skin test that can detect tuberculosis infection before the ravages of the disease are manifest. This is the setting for Cynthia Connolly’s carefully researched and informative history, Saving Sickly Children. Connolly accurately describes the response to these developments…

    N Engl J Med 360:91, January 1, 2009 Book Review

  • Chan ED, Ong CW, Hsu LY, Tambyah PA, Taha MK, Alonso JM, Siberry GK, McMillan JA, Mai NTH, Thwaites G, Farrar JJ, Scarborough M, Gordon S, Peto T
    …asserts that “the administration of dexamethasone is now widely accepted as standard practice in the management of acute bacterial meningitis in children in the industrialized world.” 1 We agree that it is a common practice but do not believe that it is widely accepted as standard practice in the…

    N Engl J Med 358:1399, March 27, 2008 Correspondence

  • Boyer D, Westra SJ, Kinane TB, Stone JR
    …such as a necrotizing pneumonia or an abscess that erodes into blood vessels are common causes of focal pulmonary hemorrhage in school-age children. 8 Tuberculosis should always be considered, especially in areas with a high prevalence. Life-threatening pulmonary hemorrhage can be seen in patients with…

    N Engl J Med 356:398, January 25, 2007 Case Records of the Massachusetts General Hospital

  • Barry M
    …pledging to wipe out the parasite by 2009. 2 Whereas massive funding is funneled into campaigns to eradicate poliovirus, to control malaria and tuberculosis, and to prevent the spread of human immunodeficiency virus, guinea worm disease is about to be eradicated without any drug therapy or vaccine. Its…

    N Engl J Med 356:2561, June 21, 2007 Perspective

  • Gold BD, Westra SJ, Graeme-Cook FM
    …infrequently in recent months. He was able to say “dada” but only babbled otherwise. No one in the family had a chronic cough or a history of tuberculosis. The temperature was 37.5°C, the pulse was 135 beats per minute, and the respiratory rate was 28 breaths per minute. The boy’s body length was…

    N Engl J Med 349:2541, December 25, 2003 Case Records of the Massachusetts General Hospital

  • Hammer AW, Hughes-Davies TH, Reichman LB, John TJ, Geng E, Schluger N
    …treatment for latent tuberculosis infection to prevent active tuberculosis. 1 Since the 1920s, BCG has been given to children in developing countries, including most on the current World Health Organization (WHO) list of tuberculosis “hot spots.” Approximately 100 million children receive BCG annually…

    N Engl J Med 347:1453, October 31, 2002 Correspondence

  • Donald PR, Schoeman JF
    …AIDS, tuberculosis is now the most common form of bacterial meningitis. In countries with a high incidence of tuberculosis, tuberculous meningitis is typically a disease of young children that develops three to six months after primary infection. In countries with a low incidence of tuberculosis, tuberculous…

    N Engl J Med 351:1719, October 21, 2004 Perspective

  • Udwadia ZF, Schaller JG, Starke J, Khatri GR, Frieden TR
    …-control programs and tuberculosis-control programs continue to be run in isolation, despite the fact that India has the world’s largest dually infected population. 5, To the Editor: Khatri and Frieden omit mention of an important population group: children. As many as half of children living in contact…

    N Engl J Med 348:758, February 20, 2003 Correspondence

  • Horsburgh CR Jr
    …reactivation tuberculosis among persons with a given medical condition in order to estimate the lifetime risk of reactivation tuberculosis among persons with that condition. Results Risk among Persons with a Nonconversion Positive Tuberculin Skin Test The rates of occurrence of tuberculosis among children with…

    N Engl J Med 350:2060, May 13, 2004 Special Article

  • Liu Y, Weinberg MS, Ortega LS, Painter JA, Maloney SA
    tuberculosis, sputum specimens were obtained on 3 consecutive days and stained for acid-fast bacilli. 19 Panel physicians made local arrangements for the radiologic and laboratory examinations required as part of the screening. 8 No mycobacterial cultures were obtained during the study period. Children

    N Engl J Med 360:2406, June 4, 2009 Original Article

  • Husson RN, Mark EJ
    …pediatric tuberculosis, 2 and there is no definitive diagnostic test for Kawasaki’s syndrome. I shall discuss this case in the context of these two disorders, as well as several others. Kawasaki’s syndrome is an idiopathic systemic vasculitis that primarily affects infants and young children. Originally…

    N Engl J Med 341:353, July 29, 1999 Case Records of the Massachusetts General Hospital

  • Severe P, Leger P, Charles M, Noel F, Bonhomme G, Bois G, George E, Kenel-Pierre S, Wright PF, Gulick R, Johnson WD Jr, Pape JW, Fitzgerald DW
    …or had lost weight. In children, the z score for weight increased from a median value of -1.8 (interquartile range, -2.6 to -1.1) at enrollment, to -1.3 at 6 months (interquartile range, -1.9 to -0.6) and to -1.2 at 12 months (interquartile range, -1.6 to -0.4). Tuberculosis Of the 910 adult and adolescent…

    N Engl J Med 353:2325, December 1, 2005 Original Article



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